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Where can I find an economical first-aid course? We also offer courses daily in the Munich city area. They are all held hinein classrooms adjacent to U/S-Bahn stations. Moosach
Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the Stützpunkt for several current therapeutic approaches.
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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion in this field that Aß may Beryllium produced from its precursor hinein a physiologically häufig pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.
Christian Haass, Professor of Metabolic Biochemistry at LMU Munich and spokesperson for the DZNE Munich, is known for his groundbreaking research rein Alzheimer's disease. His work focuses on the molecular and cellular mechanisms of this disease rein order to gain fundamental insights into its development.
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We will give you driving lessons designed to suit your own particular needs not only during the week but also on Saturdays. In this way you will get your driving licence as quickly as possible.
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Yes, a trial lesson is always possible and of course free of charge; if you decide to register with us, this trial lesson will Beryllium credited to you as "attended". I would like to register at Momo's Driving School. When can I come by?
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Leichte zweirädrige Kraftfahrzeuge mit einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht etliche als 45 kilometer pro stunde, einer Nenndauerleistung/Nutzleistung von nicht etliche als 4 kW und einem Hier Verbrennungsmotor mit einem Hubraum von nicht eine größere anzahl wie 50 zentimeter³ oder einer anderen Antriebsform.
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